geroprobПроблемы геронаукиProblems of Geroscience2949-47452949-4753АНО «ОСО ИТЕМ»10.37586/2949-4745-3-2023-127-133geroprob-16Research ArticleГлавная темаMain TopicВозрастные изменения и потеря устойчивости почечной ткани к повреждениям: роль снижения количества прогениторных клеток почки при старенииAge-Related Changes in Kidney and Loss of Resistance to Damage: The Role of the Decrease in the Number of Kidney Progenitor Cells during Aginghttps://orcid.org/0000-0002-9853-9850БуянМ. И.BuyanM. I.

Буян Марина Игоревна, младший научный сотрудник, Факультет биоинженерии и биоинформатики

Москва

Buyan Marina I., Junior researcher, Faculty of Bioengineering and Bioinformatics

Moscow

marinanenart@gmail.comhttps://orcid.org/0000-0003-2720-4575АндриановаН. В.AndrianovaN. V.

Андрианова Надежда Владимировна, канд. биол. наук, научный сотрудник лаборатории структуры и функций митохондрий

Москва

Andrianova Nadezda V., PhD in Biology, research, Laboratory of Structure and Function of Mitochondria

Moscow

andnadya12@yandex.ruhttps://orcid.org/0000-0003-2838-3704ПлотниковЕ. Ю.PlotnikovE. Y.

Плотников Егор Юрьевич, д-р биол. наук, профессор РАН, заведующий лабораторией структуры и функций митохондрий

Телефон: +7(495)939-59-44

Москва

Plotnikov Egor Y., MD, Ph.D., professor, Professor of RAS, Head of Laboratory of Structure and Function of Mitochondria

Moscow

panv@bk.ruМГУ им. М.В. ЛомоносоваРоссияLomonosov Moscow State UniversityRussian FederationНИИ физико-химической биологии имени А.Н. Белозерского, МГУ им. М.В. ЛомоносоваРоссияA.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State UniversityRussian Federation20233010202303127133Copyright © Буян М.И., Андрианова Н.В., Плотников Е.Ю., 20242024Буян М.И., Андрианова Н.В., Плотников Е.Ю.Buyan M.I., Andrianova N.V., Plotnikov E.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.geronauka.com/jour/article/view/16

В процессе старения многие органы претерпевают негативные изменения, ухудшающие их функционирование и способность к регенерации. В частности, почки с возрастом становятся более уязвимыми к острому повреждению, и повышается вероятность его перехода в хроническую болезнь почек. Во многом это может быть обусловлено снижением количества резидентных прогениторных клеток почки. В данном обзоре рассмотрены возрастные изменения, происходящие в почках на гистологическом и молекулярном уровнях, в том числе связанные с клеточным циклом, функционированием митохондрий, окислительным стрессом и хроническим воспалением. В данном обзоре описаны имеющиеся исследования резидентных стволовых клеток почек, их ниши, морфология, возможные маркеры, а также динамика их количества в процессе старения организма. На основе молекулярных и клеточных механизмов рассматриваются причины возрастного снижения регенеративного потенциала почек.

Many organs undergo negative changes during aging that affect their functions and ability to regenerate. In particular, the kidneys become more susceptible to acute injury and are more likely to develop chronic kidney disease with age. One of the reasons for this may be a decrease in the number of kidney resident progenitor cells. This review addresses age-related changes that occur in the kidneys at the histological and molecular levels, including those related to the cell cycle, mitochondrial function, oxidative stress, and chronic inflammation. This review describes the available studies on resident kidney stem cells, their niches, morphology, possible markers, and the dynamics of their numbers during the aging process. The reasons for the age-related decline in renal regenerative potential are considered based on molecular and cellular mechanisms.

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The authors declare that there are no conflicts of interest present.