geroprobПроблемы геронаукиProblems of Geroscience2949-47452949-4753АНО «ОСО ИТЕМ»10.37586/2949-4745-4-2023-185-192geroprob-27Research ArticleОбзорыReviewsСвязь нарушений липидного и углеводного обмена с основными гериатрическими синдромамиThe Impact of Lipid and Glucose Metabolism Disorders on Geriatric SyndromesКоняеваЕ. С.KoniaevaE. S.

Коняева Екатерина Сергеевна 

Москва 

Moscow 

konyaeva_es@rgnkc.ruСтражескоИ. Д.StrazheskoI. D.

Москва 

Moscow 

ФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России, Российский геронтологический научно-клинический центрРоссияPirogov Russian National Research Medical University, Russian Gerontology Research and Clinical CentreRussian Federation20233011202304185192Copyright © Коняева Е.С., Стражеско И.Д., 20242024Коняева Е.С., Стражеско И.Д.Koniaeva E.S., Strazhesko I.D.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.geronauka.com/jour/article/view/27

Основными спутниками пациентов старше 60 лет являются заболевания сердечно-сосудистой системы и гериатрические синдромы. Бесспорно, нарушения липидного и углеводного обмена увеличивают сердечно-сосудистый риск. Однако вопрос влияния показателей липидного спектра и углеводного обмена на основные гериатрические синдромы остается открытым. Известно, что роль сахарного диабета 2 типа на развитие старческой астении, саркопении, когнитивных нарушений меняется с возрастом. Если наличие хронической гипергликемии в пожилом возрасте является фактором риска развития гериатрических синдромов, то в старческом возрасте это влияние снижается, а у долгожителей приобретает нейтральную роль. Исследования последних лет показали, что среди всех показателей липидного обмена у лиц старше 60 лет низкий уровень ЛПВП ассоциирован с развитием старческой астении, саркопении, когнитивных нарушений.

In people over 60 years, the most common diseases are the cardiovascular system and geriatric syndromes. Dyslipidemia and hyperglycemia are traditional cardiovascular risk factors. However, their impact on the major geriatric syndromes development among people over 60 years remains unclear. The relationship between the presence of diabetes mellitus type 2 and the development of frailty, sarcopenia, cognitive impairment depends on age. With increasing age, the influence of chronic hyperglycemia on geriatric syndromes decreases and in centenarians it acquires a neutral role. Recent studies have shown that in people over 60 years old low HDL levels are associated with the development of frailty, sarcopenia, cognitive impairment.

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The authors declare that there are no conflicts of interest present.