References

geroprob

Проблемы геронауки

Problems of Geroscience

2949-47452949-4753

АНО «ОСО ИТЕМ»

10.37586/2949-4745-2-2024-65-74

geroprob-60

Research Article

Обзоры

Reviews

Применение биологических и таргетных синтетических базисных противовоспалительных препаратов у пациентов пожилого возраста с ревматоидным артритом: за и против

The use of biological and targeted synthetic basic anti-inflammatory drugs in elderly patients with rheumatoid arthritis: for or against

https://orcid.org/0000-0003-0622-1886

Пыхтина

В. С.

Pykhtina

V. S.

Пыхтина Валентина Сергеевна, канд. мед. наук, научный сотрудник лаборатории биомаркеров старения

Москва

Pykhtina Valentina S., MD, PhD, researcher, the Laboratory of Biomarkers of Aging

Moscow

Pyhtina_vs@rgnkc.ru

https://orcid.org/0000-0002-2028-3939

Мачехина

Л. В.

Machekhina

L. V.

Мачехина Любовь Викторовна, канд. мед. наук, заведующая лабораторией биомаркеров старения

Москва

Machekhina Lubov V., MD, PhD, Head ofthe Laboratory of Biomarkers of Aging

Moscow

mlv66@list.ru

https://orcid.org/0000-0002-5187-0108

Мешков

А. Д.

Meshkov

A. D.

Мешков Алексей Дмитриевич, канд. мед. наук, врач-ревматолог, старший научный сотрудник лаборатории заболеваний костно-мышечной системы Российского геронтологического научно-клинического центра

Москва

Телефон: +7(916)174-42-04

Meshkov Alexey D., MD, PhD, senior researcher, Laboratory of diseases of the musculoskeletal system

Moscow

Tel. +7(916)174-42-04

alexeymeshkov@mail.ru

https://orcid.org/0000-0002-3657-0676

Стражеско

И. Д.

Strazhesko

I. D.

Стражеско Ирина Дмитриевна, д-р мед. наук, заместитель директора по трансляционной медицине; ведущий научный сотрудник отдела возраст-ассоциированных заболеваний медицинского научно-образовательного центра МГУ им. М.В. Ломоносова

Москва

Телефон: +7(903)520-41-54

Strazhesko Irina D., MD, PhD, professor, Deputy Director for Translational Medicine, Russian Gerontology Research and Clinical Centre; Leading researcher at the Department of Age-related diseases

Moscow

+7(903)520-41-54

istrazhesko@gmail.com

ФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава РоссииРоссияRussian Gerontology Clinical Research Center of Pirogov Russian National Research Medical University of Ministry of Healthcare of the Russian FederationRussian Federation

2024

30062024

026574

2024

Пыхтина В.С., Мачехина Л.В., Мешков А.Д., Стражеско И.Д.

Pykhtina V.S., Machekhina L.V., Meshkov A.D., Strazhesko I.D.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.geronauka.com/jour/article/view/60

В связи с глобальным старением населения и увеличением продолжительности жизни растет доля пожилых пациентов с ревматоидным артритом — как за счет пациентов с дебютом после 60 лет, так и пожилых пациентов, у которых заболевание стартовало в молодом возрасте. Лечение таких пациентов сопряжено с рядом сложностей, что связано с особенностями старения иммунной системы и организма в целом, бременем коморбидных состояний. Пожилые пациенты, в отличие от молодых, имеют более высокие риски развития нежелательных явлений при назначении как синтетических, так и биологических препаратов. Эти особенности ведут к более щадящей стратегии лечения пожилых пациентов, ограничению применения адекватных доз базисных препаратов и низкому числу назначения биологических препаратов. В данной статье приводятся актуальные данные о безопасности и эффективности применения биологических и таргетных синтетических базисных противовоспалительных препаратов у пожилой категории пациентов с ревматоидным артритом.

Due to the global aging of the population and increasing life expectancy, the population of elderly patients with rheumatoid arthritis is growing, both due to patients with onset after 60 years of age (EORA), and elderly patients in whom the disease started at a young age. Treatment of such patients is associated with a number of difficulties, which is associated with the characteristics of the aging of the immune system and the body as a whole, and the burden of comorbid conditions. Elderly patients, unlike young ones, have a higher risk of developing adverse events when prescribed both basic and biological drugs. These features lead to a more “gentle” treatment strategy for elderly patients, limited use of adequate doses of basic drugs and a low number of prescriptions of biological drugs among doctors. This article provides current data on the safety and effectiveness of the use of biological and targeted synthetic disease-modifying anti-inflammatory drugs in elderly patients with rheumatoid arthritis.

РАРА с дебютом в пожилом возрастеиИЛ-6иЯКиФНО-αритуксимабабатацепт

EORAiTNFRAiIL-6iJAKrituximababatacept

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The authors declare that there are no conflicts of interest present.