geroprobПроблемы геронаукиProblems of Geroscience2949-47452949-4753АНО «ОСО ИТЕМ»10.37586/2949-4745-3-2024-131-140geroprob-68Research ArticleОбзорыReviewsАссоциации ИФР-1 и ИФРСБ-3 со старением и развитием возраст-ассоциированных заболеванийAssociations of IGF-1 and IGFBP-3 with aging and the development of age-associated diseaseshttps://orcid.org/0000-0002-3544-5347ИльющенкоА. К.IlyushchenkoA. K.

Ильющенко Анна Константиновна, врач-терапевт, младший научный сотрудник лаборатории биомаркеров старения 

Москва

Ilyushchenko Anna K., MD, internist

Moscow

Ilyushchenko_ak@rgnkc.ruhttps://orcid.org/0000-0002-2028-3939МачехинаЛ. В.MatchekhinaL. V.

Мачехина Любовь Викторовна, канд. мед. наук, заведующая лабораторией биомаркеров старения

Москва

Machekhina Lubov V., MD, PhD, Head of the Laboratory of Biomarkers of Aging

Moscow

machehina_lv@rgnkc.ruhttps://orcid.org/0009-0009-0858-2053МельницкаяА. А.MelnitskaiaA. A.

Мельницкая Александра Андреевна, врач-гериатр, младший научный сотрудник лаборатории биомаркеров старения

Москва

Melnitskaia Aleksandra A., MD, geriatrician, Junior Researcher, Laboratory of Biomarkers of Aging

Moscow

melnickaya_aa@rgnkc.ruhttps://orcid.org/0000-0002-3657-0676СтражескоИ. Д.StrazheskoI. D.

Стражеско Ирина Дмитриевна, д-р мед. наук, заместитель директора по трансляционной медицине; ведущий научный сотрудник отдела возраст-ассоциированных заболеваний медицинского научно-образовательного центра МГУ им. М.В. Ломоносова

Москва

Strazhesko Irina D., MD, PhD, Deputy Director for Translational Medicine; Leading Researcher at the Department of Age-Related Diseases, Medical Scientific  and Educational Center of Lomonosov Moscow State University

Moscow

strazhesko_id@rgnkc.ruФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России (Пироговский Университет), ОСП «Российский геронтологический научно-клинический центр»РоссияRussian Gerontology Research and Clinical Centre, Pirogov Russian National Research Medical UniversityRussian Federation20242009202403131140Copyright © Ильющенко А.К., Мачехина Л.В., Мельницкая А.А., Стражеско И.Д., 20242024Ильющенко А.К., Мачехина Л.В., Мельницкая А.А., Стражеско И.Д.Ilyushchenko A.K., Matchekhina L.V., Melnitskaia A.A., Strazhesko I.D.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.geronauka.com/jour/article/view/68

Старение представляет собой биологический процесс, который затрагивает множество систем организма и сопровождается изменениями на молекулярном, клеточном и физиологическом уровнях. Одним из ключевых элементов в изучении старения является определение роли инсулиноподобных факторов роста (ИФР) и инсулиноподобных связывающих белков (ИФРСБ). ИФР, в частности ИФР-1, играют важную роль в регуляции клеточного роста, метаболизма и апоптоза. ИФРСБ, в особенности ИФРСБ-3, регулируют биодоступность ИФР, связывая их и модулируя их взаимодействие с рецепторами. В данной статье рассматриваются преимущественно механизмы действия ИФР-1 и ИФРСБ-3, а также данные клинических исследований, изучающих их роль в процессе старения, долголетии и развитии возраст-ассоциированных заболеваний. Для исследования связи ИФР и ИФРСБ с процессами старения был проведен поиск по базам статей Scopus и PubMed. Были отобраны фундаментальные и клинические исследования, опубликованные преимущественно в период с 2010 по 2024 год. Поиск проводился по ключевым словам «инсулиноподобные факторы роста», «инсулиноподобные связывающие белки», «старение», «возраст-ассоциированные заболевания».

Aging is a complex biological process impacting various systems of the body, with changes occurring at molecular, cellular, and physiological levels. This review focuses on the role of insulin-like growth factors (IGFs) and insulinlike growth factor-binding proteins (IGFBPs) in aging process. IGF-1 is crucial for the regulation of cell growth, metabolism, and apoptosis, while IGFBP-3 modulates the bioavailability of IGFs by binding to them and influencing their receptor interactions. This article outlines the mechanisms of action of IGF-1 and IGFBP-3 and discusses clinical research findings on their significance in aging, longevity, and the development of age-associated diseases. A literature search was conducted using Scopus and PubMed databases, focusing on fundamental and clinical studies. The search utilized keywords such as «insulin-like growth factors», «insulin-like growth factor-binding proteins», «aging» and «ageassociated diseases».

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The authors declare that there are no conflicts of interest present.