geroprobПроблемы геронаукиProblems of Geroscience2949-47452949-4753АНО «ОСО ИТЕМ»10.37586/2949-4745-4-2024-171-180geroprob-71Research ArticleОбзорыReviewsНеалкогольная жировая болезнь печени и остеопороз: двунаправленная связьNon-alcoholic fatty liver disease and osteoporosis: a bi-directional associationhttps://orcid.org/0000-0001-7891-6850ДудинскаяЕ. Н.DudinskayaE. N.

Дудинская Екатерина Наильевна

Москва

 Moscow 

dudinskaya_en@rgnkc.ruhttps://orcid.org/0000-0002-0556-1697ОнучинаЮ. С.OnuchinaYu. S.

Москва

 Moscow 

onuchina90@list.ruФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России (Пироговский Университет), ОСП «Российский геронтологический научно-клинический центр», Лаборатория возрастных метаболических и эндокринных заболеваний; ФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России (Пироговский Университет), Кафедра болезней старения Института непрерывного образования и профессионального развития ФДПОРоссияLaboratory of Endocrine and Metabolic Disorders, Russian Gerontology Research and Clinical Centre, Pirogov National Research Medical University; Department of Aging Diseases, Faculty of Additional Professional Education, Pirogov National Research Medical UniversityRussian FederationФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России (Пироговский Университет), ОСП «Российский геронтологический научно-клинический центр», Лаборатория возрастных метаболических и эндокринных заболеванийРоссияLaboratory of Endocrine and Metabolic Disorders, Russian Gerontology Research and Clinical Centre, Pirogov National Research Medical UniversityRussian Federation20241312202404171180Copyright © Дудинская Е.Н., Онучина Ю.С., 20252025Дудинская Е.Н., Онучина Ю.С.Dudinskaya E.N., Onuchina Y.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.geronauka.com/jour/article/view/71

Остеопороз является серьезной проблемой для здравоохранения во всем мире, характеризуется низкой минеральной плотностью кости (МПК) и нарушением микроархитектоники костной ткани, что приводит к увеличению частоты низкотравматичных переломов. Остеопороз чаще выявляют у пожилых людей, но он может возникнуть и в более раннем возрасте вследствие нарушения усвоения кальция и витамина Д при различных желудочно-кишечных (ЖКТ) заболеваниях.

Неалкогольная жировая болезнь печени (НАЖБП) является фактором риска снижения минеральной плотности кости (МПК). Представлены новые данные о патофизиологических изменениях костной ткани при НАЖБП: высвобождение воспалительных цитокинов, снижение секреции молекул, непосредственно влияющих на кость, нарушение метаболизма витамина D, нарушение кишечной микробиоты. НАЖБП является фактором риска снижения МПК.

Подтверждение физиологической значимости НАЖБП в отношении риска остеопоротических переломов костей требует дальнейшего изучения. Возможно, обязательный скрининг остеопороза и наблюдение за состоянием костей у пациентов с НАЖБП будет возможен в будущих стратегиях и руководствах.

Osteoporosis is a serious public health concern worldwide, characterized by decreased bone mineral density (BMD) and impaired microarchitecture of bone tissue, leading to an increased incidence of low-trauma fractures. Osteoporosis typically affects older adults, but it can also occur at younger ages due to impaired absorption of calcium and vitamin D in various gastrointestinal (GI) diseases. NAFLD is a risk factor for decreased bone mineral density (BMD). New data on the pathophysiological changes in bone tissue in NAFLD are presented: release of inflammatory cytokines, decreased secretion of molecules directly affecting bone (strengthening bone) from the liver affected by NAFLD, impaired vitamin D metabolism, and impaired intestinal microbiota. NAFLD is a risk factor for decreased BMD.

Further research is needed to confirm the physiological significance of NAFLD with regard to the risk of osteoporotic bone fractures. Mandatory osteoporosis screening and bone health monitoring in patients with NAFLD may be possible in future NAFLD management strategies and guidelines.

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The authors declare that there are no conflicts of interest present.