References

geroprob

Проблемы геронауки

Problems of Geroscience

2949-47452949-4753

АНО «ОСО ИТЕМ»

10.37586/2949-4745-3-2024-141-153

geroprob-73

Research Article

Обзоры

Reviews

Роль сна в процессах старения

The role of sleep in the aging processes

https://orcid.org/0000-0002-5702-0630

Исаев

Р. И.

Isaev

R. I.

Исаев Руслан Ибрагимович, младший научный сотрудник лаборатории нейрогериатрии

Москва

Isaev Ruslan I., MD, Junior Researcher, Laboratory of Neurogeriatrics

Moscow

isaev-doc@mail.ru

https://orcid.org/0000-0003-2597-981X

Мхитарян

Э. А.

Mkhitaryan

E. A.

Мхитарян Элен Араиковна, канд. мед. наук, доцент кафедры болезней старения, заведующая лабораторией нейрогериатрии

Москва

Mkhitaryan Elen A., MD, PhD, Associate Professor, Age-Related Diseases Department, Head of the Laboratory of Neurogeriatrics

Moscow

https://orcid.org/0000-0002-9054-0881

Чердак

М. А.

Cherdak

M. A.

Чердак Мария Алексеевна, канд. мед. наук, доцент кафедры болезней старения

Москва

Cherdak Maria A., MD, PhD, Associate Professor, AgeRelated Diseases Department, Senior Researcher, Laboratory of Neurogeriatrics

Moscow

https://orcid.org/0009-0006-7936-7308

Василевская

В. В.

Vasilevskaya

V. V.

Василевская Виктория Виталиевна, ординатор

Москва

Vasilevskaya Victoria V., Resident

Moscow

https://orcid.org/0000-0001-7413-646X

Мараховская

Е. А.

Marakhovskaya

E. A.

Мараховская Елизавета Андреевна, студентка 5-го курса

Москва

Marakhovskaya Yelyzaveta А., 5th year student

Moscow

https://orcid.org/0000-0003-4188-1898

Арбатский

М. С.

Arbatskiy

M. S.

Арбатский Михаил Спартакович, канд. экон. наук, заведующий лабораторией искусственного интеллекта и биоинформатики

Москва

Arbatskiy Mikhail S., MD, PhD, Head of the Laboratory of Artificial Intelligence and Bioinformatics

Moscow

ФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России (Пироговский университет), Российский геронтологический научно-клинический центрРоссияRussian Gerontology Research and Clinical Centre, Pirogov Russian National Research Medical UniversityRussian Federation

ФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России (Пироговский университет)Russian FederationPirogov Russian National Research Medical UniversityRussian Federation

2024

20092024

03141153

2024

Исаев Р.И., Мхитарян Э.А., Чердак М.А., Василевская В.В., Мараховская Е.А., Арбатский М.С.

Isaev R.I., Mkhitaryan E.A., Cherdak M.A., Vasilevskaya V.V., Marakhovskaya E.A., Arbatskiy M.S.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.geronauka.com/jour/article/view/73

Сон, являясь жизненно необходимой потребностью организма, связан со многими важными биологическими процессами. Старение — один из естественных биологических процессов, оказывающих влияние на все функции человеческого организма. Изучение связи между сном и старением вызывает оживленный интерес исследователей в последние годы. В статье обсуждаются современные взгляды о роли сна в процессах старения и его геропротективный потенциал. В статье приводятся данные по изучению влияния нарушения сна на ключевые признаки старения. Обсуждается влияние депривации сна, инсомнии и синдрома обструктивного апноэ сна на девять ключевых признаков старения, выделенных López-Otín C. и соавторами: нестабильность генома, укорочение теломер, потерю протеостаза, эпигенетические модификации, нарушение распознавания питательных веществ, дисфункцию митохондрий, истощение пула стволовых клеток, клеточное старение и изменение внутриклеточного взаимодействия. Также приводятся данные о сомнологических биомаркерах и их связи с индексом возраста мозга, затрагиваются вопросы влияния сна на формирование нейродегенеративных расстройств, в том числе болезни Альцгеймера. Один из разделов посвящен обзору данных литературы на тему значимости циркадных ритмов в развитии нейродегенерации и процессов старения. В качестве геропротективных методов рассматривается применение светотерапии и мелатонина. В заключении обсуждается актуальность развития геронтосомнологии.

Sleep, being a fundamental requirement for the body’s well-being, plays a crucial role in various essential biological processes. Aging is one of the natural biological processes that affects all functions of the human body. The relationship between sleep and aging has been a subject of significant interest of researchers in recent years. The article discusses modern views on the role of sleep in the aging processes and its geroprotective potential. The article provides data on the study of the effect of sleep disorders on hallmarks of aging. The influence of sleep deprivation, insomnia and obstructive sleep apnea syndrome on nine hallmarks of aging according to the classification developed by López-Otín et al., is discussed: genomic instability, telomere attrition, loss of proteostasis, epigenetic alterations, deregulated nutrient sensing, mitochondrial dysfunction, stem cell exhaustion, cellular senescence and alter intracellular communication. Data on somnological biomarkers and their relationship to the brain age index are also provided, and the influence of sleep on the formation of neurodegenerative disorders, including Alzheimer's disease, is discussed. One of the sections is reviews data on the significance of circadian rhythms in the development of neurodegeneration and aging processes. The use of light therapy and melatonin is considered as geroprotective methods. Finnely, the article discusses the importance of developing gerontosomnology.

сонстарениегеропротективные методыдепривация снаинсомниясиндром обструктивного апноэ снаключевые признаки старениястарение мозгаболезнь Альцгеймерациркадные ритмысветотерапиямелатонингеронтосомнология

sleepaginggeroprotective methodssleep deprivationinsomniaobstructive sleep apnea syndromehallmarks of agingbrain agingAlzheimer's diseasecircadian rhythmslight therapymelatoningerontosomnology

Работа выполнена в рамках программы «Приоритет–2030»

This work was carried out with financial support from the Priority 2030 programme.

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The authors declare that there are no conflicts of interest present.