Association between Telomere Length and Geriatric Status in Centenarians
https://doi.org/10.37586/2949-4745-2-2023-102-107
Abstract
Aim. To evaluate the association between telomere length and frailty and individual geriatric syndromes in older adults.
Materials and methods. The database of a hundred-year-old citizen of the city of Moscow was analyzed. The analysis was carried out using the data driven from the Comprehensive Geriatric Assessment (CGA), in particular, Age is not a Hindrance Scale, the Barthel index, Instrumental Activities of Daily Living (IADL), Mini Nutritional Assessment (MNA), Mini-Mental State Examination (MMSE), and Geriatric Depression Scale (GDS-15). DNA was isolated from frozen blood and a study of telomere length was performed. The comparison of telomere length in groups of patients with frailty and individual geriatric syndromes was carried out.
Results. The study involved 60 people (98±1.8 years, 86.7% women). The analysis found no differences in telomere length in study participants with and without frailty, as well as in the analysis of individual geriatric syndromes. No correlation was found between telomere length and the results of comprehensive geriatric assessment scales. There was no difference in telomere length in patients who died within 3 years of follow-up and no.
Conclusion. No relationship was found between telomere length and frailty. Thus, telomere length cannot be considered as a reliable biomarker of functional aging.
About the Authors
K. A. Eruslanova
Russian Gerontology Research and Clinical Centre, Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Ksenia A. Eruslanova, MD, PhD, Head of Laboratory
Laboratory of Cardiovascular Aging
Moscow
Phone: +7(499)1877809
S. O. Zhikrivetskaya
Veltischev Research and Clinical Institute for Pediatrics and Pediatric Surgery of the Pirogov Russian National Research Medical University; The «GENETICO» Center of Genetics and Reproductive Medicine
Russian Federation
Russian Federation
Svetlana Olegovna Zhikrivetskaya, PhD in Biology, Researcher
Moscow
Yu. V. Kotovskaya
Russian Gerontology Research and Clinical Centre, Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Yulia V. Kotovskaya, MD, PhD, professor, Deputy Director
Moscow
Phone: +7(499)1877809
O. N. Tkacheva
Russian Gerontology Research and Clinical Centre, Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Olga N. Tkacheva, MD, PhD, professor, corresponding member of the Russian Academy of Sciences, Director
Moscow
Phone: +7(499)1876467
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For citations:
Eruslanova K.A., Zhikrivetskaya S.O., Kotovskaya Yu.V., Tkacheva O.N. Association between Telomere Length and Geriatric Status in Centenarians. Problems of Geroscience. 2023;(2):102-107. (In Russ.) https://doi.org/10.37586/2949-4745-2-2023-102-107
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