Возрастные изменения и потеря устойчивости почечной ткани к повреждениям: роль снижения количества прогениторных клеток почки при старении
https://doi.org/10.37586/2949-4745-3-2023-127-133
Аннотация
В процессе старения многие органы претерпевают негативные изменения, ухудшающие их функционирование и способность к регенерации. В частности, почки с возрастом становятся более уязвимыми к острому повреждению, и повышается вероятность его перехода в хроническую болезнь почек. Во многом это может быть обусловлено снижением количества резидентных прогениторных клеток почки. В данном обзоре рассмотрены возрастные изменения, происходящие в почках на гистологическом и молекулярном уровнях, в том числе связанные с клеточным циклом, функционированием митохондрий, окислительным стрессом и хроническим воспалением. В данном обзоре описаны имеющиеся исследования резидентных стволовых клеток почек, их ниши, морфология, возможные маркеры, а также динамика их количества в процессе старения организма. На основе молекулярных и клеточных механизмов рассматриваются причины возрастного снижения регенеративного потенциала почек.
Ключевые слова
При поддержке: Работа поддержана Российским научным фондом (грант 21-75-30009).
Об авторах
М. И. Буян
МГУ им. М.В. Ломоносова
Россия
Россия
Буян Марина Игоревна, младший научный сотрудник, Факультет биоинженерии и биоинформатики
Москва
Н. В. Андрианова
НИИ физико-химической биологии имени А.Н. Белозерского, МГУ им. М.В. Ломоносова
Россия
Россия
Андрианова Надежда Владимировна, канд. биол. наук, научный сотрудник лаборатории структуры и функций митохондрий
Москва
Е. Ю. Плотников
НИИ физико-химической биологии имени А.Н. Белозерского, МГУ им. М.В. Ломоносова
Россия
Россия
Плотников Егор Юрьевич, д-р биол. наук, профессор РАН, заведующий лабораторией структуры и функций митохондрий
Телефон: +7(495)939-59-44
Москва
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Рецензия
Для цитирования:
Буян М.И., Андрианова Н.В., Плотников Е.Ю. Возрастные изменения и потеря устойчивости почечной ткани к повреждениям: роль снижения количества прогениторных клеток почки при старении. Проблемы геронауки. 2023;(3):127-133. https://doi.org/10.37586/2949-4745-3-2023-127-133
For citation:
Buyan M.I., Andrianova N.V., Plotnikov E.Y. Age-Related Changes in Kidney and Loss of Resistance to Damage: The Role of the Decrease in the Number of Kidney Progenitor Cells during Aging. Problems of Geroscience. 2023;(3):127-133. (In Russ.) https://doi.org/10.37586/2949-4745-3-2023-127-133
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