Basic Epigenetic Mechanisms of Aging
https://doi.org/10.37586/2949-4745-2-2023-88-93
Abstract
The process of aging is a complex biological phenomenon that is influenced by multiple factors, including genetics, environment, and lifestyle. Recent studies have shown that epigenetic modifications play an important role in the aging process, as they regulate gene expression and ultimately affect cellular function. Epigenetic modifications include DNA methylation, histone modification, and non-coding RNA expression, among others. The authors of the review discuss the role of DNA methylation in regulating gene expression and its relationship to age-related diseases such as cancer and neurodegeneration. Also, the role of histone modification and its impact on chromatin structure and gene expression is reviewed in the article. Additionally, review provides information on involvement of molecular hallmarks of aging in age-related diseases. Understanding the role of epigenetic mechanisms in aging is crucial for developing new interventions that could potentially slow down or even reverse the aging process.
About the Authors
I. D. Strazhesko
Pirogov Russian National Research Medical University, Russian Gerontology Research and Clinical Centre; Medical Scientific and Educational Center of Lomonosov Moscow State University
Russian Federation
Russian Federation
Irina D. Strazhesko, MD, PhD, Deputy Director for Translational Medicine, Leading Researcher
Department of Age Related Diseases
Moscow
Phone: +7(903)5204154
A. P. Yesakova
Moscow State University of Medicine and Dentistry
Russian Federation
Russian Federation
Antonina P. Yesakova, MD, Assistant Professor
Department of Medical Genetics Moscow
Moscow
Phone: +7(906)7020713
A. A. Akopyan
Pirogov Russian National Research Medical University, Russian Gerontology Research and Clinical Centre
Russian Federation
Russian Federation
Anna A. Akopyan, MD, Junior Researcher
Laboratory of Biomarkers of Aging
Moscow
Phone: +7(903)7455788
O. N. Tkacheva
Pirogov Russian National Research Medical University, Russian Gerontology Research and Clinical Centre
Russian Federation
Russian Federation
Olga N. Tkacheva, MD, PhD, professor, corresponding member of the Russian Academy of Sciences, Director
Moscow
Phone: +7(499)1876467
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Review
For citations:
Strazhesko I.D., Yesakova A.P., Akopyan A.A., Tkacheva O.N. Basic Epigenetic Mechanisms of Aging. Problems of Geroscience. 2023;(2):88-93. (In Russ.) https://doi.org/10.37586/2949-4745-2-2023-88-93
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