Associations of IGF-1 Level With Some Indicators of Hormonal and Metabolic Status and its Role in the Annual Prognosis in People Aged 90 Years and Older

A. K. Ilyushchenko; L. V. Machekhina; O. N. Tkacheva; E. M. Shelley; A. A. Mamchur; V. V. Erema; M. V. Ivanov; D. A. Kashtanova; A. M. Rumyantseva; V. S. Yudin; V. V. Makarov; A. A. Keskinov; S. A. Kraevoy; S. M. Yudin; I. D. Strazhesko

Associations of IGF-1 Level With Some Indicators of Hormonal and Metabolic Status and its Role in the Annual Prognosis in People Aged 90 Years and Older

A. K. Ilyushchenko, L. V. Machekhina, O. N. Tkacheva, E. M. Shelley, A. A. Mamchur, V. V. Erema, M. V. Ivanov, D. A. Kashtanova, A. M. Rumyantseva, V. S. Yudin, V. V. Makarov, A. A. Keskinov, S. A. Kraevoy, S. M. Yudin, I. D. Strazhesko

Full Text:

PDF (Rus)

Generate QR code

Abstract

Relevance. Many studies have confirmed an age-associated decrease in the level of insulin-like growth factor 1 (IGF-1), which contributes to changes in a number of hormonal and metabolic processes. However, there is insufficient information about what level of IGF-1 is optimal in old age and whether maintaining a certain concentration of IGF-1 can have a positive effect and be a protective factor. Data obtained on a unique cohort of centenarians is especially limited, which determines the relevance of this study.

Aim. The paper aimed to study the association between higher and lower levels of IGF-1 with biomarkers of hormonal and metabolic status and determine its role in the one-year prognosis of centenarians.

Materials and methods. As part of a cross-sectional study, a cohort of people aged 90 years and older. Serum IGF-1 levels were measured using a chemiluminescent assay. Differences in survival between the high and low IGF-1 groups were assessed based on the results of one-year follow-up. The study was approved by the local ethics committee (protocol No. 30 of December 24, 2019). Statistical data analysis was carried out using the R programming language version 4.2.2.

Results. The study included 2893 people aged 90 to 107 years who met the inclusion criteria. The mean age was 92 years; the median IGF-1 level was 99.6 ng/ml. According to the results of intergroup comparison, a significant relationship with the level of IGF-1 was shown by the level of insulin, glycated hemoglobin, total protein, albumin and C-reactive protein (p-value < 0.001). The group of participants with higher IGF-1 levels (above the median — 9.6 ng/ml) had significantly higher levels of total protein, albumin and glycated hemoglobin and lower levels of C-reactive protein and insulin. When constructing logistic regression models and adjusting for the level of physical activity, statistical significance remained only for the association of IGF-1 levels and laboratory parameters such as insulin, glycated hemoglobin and albumin. When analyzing the survival of participants with high and low IGF-1 levels, higher (above the median) IGF-1 values were found to be a protective factor for the survival of subjects aged 90 years and older.

Conclusions. According to the results, higher IGF-1 levels were associated with better 1-year survival in subjects aged 90 years and older. In addition, bidirectional associations between IGF-1 and laboratory markers such as albumin, insulin and glycated hemoglobin were found. A more detailed analysis of the identified associations to determine the optimal level of IGF-1 to maintain metabolic processes among centenarians in different populations is required.

Keywords

centenarians, IGF-1, insulin, albumin, glycated hemoglobin

About the Authors

A. K. Ilyushchenko

Russian Gerontology Research and Clinical Centre, Pirogov Russian National Research Medical University
Russian Federation

Moscow

L. V. Machekhina

Russian Gerontology Research and Clinical Centre, Pirogov Russian National Research Medical University
Russian Federation

Moscow

O. N. Tkacheva

Russian Gerontology Research and Clinical Centre, Pirogov Russian National Research Medical University
Russian Federation

Moscow

E. M. Shelley

Russian Gerontology Research and Clinical Centre, Pirogov Russian National Research Medical University
Russian Federation

Moscow

A. A. Mamchur